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Error 550 5.7.0 Relay Access Denied in Server 2013 Enterprise

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Good evening everyone.

When emails are sent from outside of our domain, to our domain; the following message is returned:

Delivery to the following recipient failed permanently:

     email

Technical details of permanent failure 

Google tried to deliver your message, but it was rejected by the server for the recipient domain  by mail messaging microsoft 

The error that the other server returned was:

550 5.7.0 Relay Access Denied

It is affecting all users.

I have scoured the net and tried many solutions.  I have disabled both the anti-spam software and Symantec.

I am at a loss.  I am willing to try a reconfigure that doesn't require an outside relay or try and fix this issue but the system has been down for the organization for too long.

Any advice is appreciated!

Thank you


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