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Exchange 2010 outbound emails stuck in queue - 451 error

Hello,

We have an Exchange 2010 server that was sending emails ok until the Internet connection changed ISP.

All emails get stuck in the queue with the following error:

451 4.4.0 Primary targeted IP address responded with: "421 4.2.1 Unable to connect." Attempted failover to alternate hosts, or delivery failed to alternate hosts.

Anyone have any ideas please?!


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