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451 4.4.0 Primary target IP address responded with: "421 4.4.5 Service not available, connection deferred

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Hi,

We have exchange server 2013. The issue is that emails are stucked in queue for one domain. We have no issue sending emails to all other domains i.e gmail, yahoo etc'

Users are getting the following messages:

Remote
Server at mail.server.com (xxx.xxx.xxx.xxx) returned '400 4.4.7 Message
delayed'

3/22/2015 2:26:30 AM - Remote Server at mail.server.com
(xxx.xxx.xxx.xxx) returned '451 4.4.0 Primary target IP address responded with:
"421 4.4.5 Service not available, connection deferred." Attempted
failover to alternate host, but that did not succeed. Either there are no
alternate hosts, or delivery failed to all alternate hosts. The last endpoint
attempted was xxx.xxx.xxx.xxx:25'

Any thoughts please?

Regards,

Anees


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