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Exchange 2013 can't send re recieve

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Hello,

I have Exchange 2013 SP1 all on single machine this issue is repeated 3 times in one week suddenly every thing stops the client getting different messages  one of them " 451 4.7.0 Temporary server error. Please try again later. PRX4 "

also the exchange toolbox not working and exchange queue viewer give the below screen :-

also the Exchange power shell not working at all i'm getting confused please check the below screen also :-

i checked all services all services in running stat however the transport service was in starting stat then i restart it but still all issues , Please advise.


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