LED=441 4.4.1 Error encounteredwhile communicating...

My problem is with mail flow.   If I go into the Exchange 2013 toolbox and open the queue viewer I can see over a hundred messages stacking up.  What do I do to stop these errors?

In the Queues tab under Last Error I see the following error; majority of these errors in the "From Address" is<>

"[{LRT=(date\time);{LED=441 4.4.1 Error encountered while communicating with primary target IP addrress; "Failed to connect. Winsock error code: 10060, Win32 error code 10060. Attempted failover to alternate host, but that did not succeed. Either the" (the rest of the error message is cut off)

Win2012/Ex2013 sp1

PennyM