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mail failed to deliver

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hi all , 

recently we have added new Exchange Server Node ( one CAS/HUB and one Mail box ) to our environment exchange 2013 .

we trying to send email to outside some emails are going and other are failed to deliver with below NDR : 

Remote Server at [172.20.1.24] (172.20.1.24) returned '400 4.4.7 Message delayed' 1/10/2016 2:37:42 PM - Remote Server at [172.20.1.24] (172.20.1.24) returned '441 4.4.1 Error encountered while communicating with primary target IP address: "Failed to connect. Winsock error code: 10060, Win32 error code: 10060." Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts. The last endpoint attempted was 172.20.1.24:25'

when shutdown the new add mailbox server all are working fine any idea ? 


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