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Sudden Mail Flow Issues

Using Exchange 2013 CU11 on Windows Server 2008 R2.  Upgraded from CU9 and issues didn't seem to happen then -- this is a testing environment before I deploy the server.

Outlook 2010 connects fine, can compose email and send but it never goes anywhere, doesn't show up in the Exchange Toolbox Queue.  If I use OWA the mail stays in the Drafts folder when I click Send.  When I try to send again it says "you do not have permission to perform this action"  Finally, if I compose something in Outlook 2010 or OWA it will hit the Drafts folder if I "save" it so I know they are communicating correctly.

I have searched for the issue on the Internet and tried all DNS, host file, Exchange fixes I can find but still no luck.  My MX record is correct and the Receive Connectors are all default.  This server is not internet connected at the moment and I am just trying to route mail internally from a few mailboxes I have created.  AD, DNS are on the same machine as we only have one server at the moment.  I was fine with CU9 but then did Windows Updates and CU11 update and this happened.  Also, we use POP3 and I tried via that method and it won't accept any authentication so there are definitely a few things going on.


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