Using Exchange 2013 CU11 on Windows Server 2008 R2. Upgraded from CU9 and issues didn't seem to happen then -- this is a testing environment before I deploy the server.
Outlook 2010 connects fine, can compose email and send but it never goes anywhere, doesn't show up in the Exchange Toolbox Queue. If I use OWA the mail stays in the Drafts folder when I click Send. When I try to send again it says "you do not have permission to perform this action" Finally, if I compose something in Outlook 2010 or OWA it will hit the Drafts folder if I "save" it so I know they are communicating correctly.
I have searched for the issue on the Internet and tried all DNS, host file, Exchange fixes I can find but still no luck. My MX record is correct and the Receive Connectors are all default. This server is not internet connected at the moment and I am just trying to route mail internally from a few mailboxes I have created. AD, DNS are on the same machine as we only have one server at the moment. I was fine with CU9 but then did Windows Updates and CU11 update and this happened. Also, we use POP3 and I tried via that method and it won't accept any authentication so there are definitely a few things going on.