Emails inbound from some domains are failing

Have Exchange 2010 running on a VmWare virtual server.  Generally the mail is flowing however with SOME domains (maybe 3 at the most) the Sender is getting the following message when they try to send an email to our domain. 

One more note:  We have no problem internally sending an email to the external domains in question.  The only issue is when the external domain try to send emails to our domain. 

From: Microsoft Outlook

Sent: Friday, February 19, 2016 1:45 PM
To: XXXXXX
Subject: Delivery delayed:testing

Delivery is delayed to these recipients or groups:

"from external to internal"

Subject: testing

This message hasn't been delivered yet. Delivery will continue to be attempted.

The server will keep trying to deliver this message for the next 1 days, 19 hours and 55 minutes. You'll be notified if the message can't be delivered by that time.

I have done the following to try and troubleshoot:

1. Check packet monitor on firewall

2. Created exemptions for troubled domains on both firewall and Content filter

I could use some help on this issue. 

Thanks in advance. 

Here is an example of the Message Header from one conversation:

Diagnostic information for administrators:

Generating server: somewhere-EXCHANGE.somewhere.local

jblog@x.x.x.us
#550 4.4.7 QUEUE.Expired; message expired ##

Original message headers:

Received: from somewhere-EXCHANGE.somewhere.local ([192.0.0.xxx]) by

 somewhere-Exchange.somewhere.local ([192.0.0.xxx]) with mapi id 14.03.0224.002; Wed,

 17 Feb 2016 09:38:41 -0700

From: June Blue <xxxx@somewhere.org>

To: Joe Blog   <xxxx@x.x.x.us>

Subject: RE: Dawn to Dusk golf tournament? 

Thread-Topic: Dawn to Dusk golf tournament? 

Thread-Index: AQHRaaClmcoaVPTI1kqZ4Tk2TGF2aJ8wb95Q

Date: Wed, 17 Feb 2016 16:38:41 +0000

Message-ID: <A855B4CFDC8C714A8591D46542978D80B7DF4887@somewhere-Exchange.somewhere.local>

References: <2E900A3EA21D8143A494968D0618758101695A82F9@MSEXCHANGE.x.x.x.us>

In-Reply-To: <2E900A3EA21D8143A494968D0618758101695A82F9@MSEXCHANGE.x.x.x.us>

Accept-Language: en-US

Content-Language: en-US

X-MS-Has-Attach: yes

X-MS-TNEF-Correlator:

x-originating-ip: [192.0.x.xxx]

Content-Type: multipart/related;

        boundary="_010_A855B4CFDC8C714A8591D46542978D80B7DF4887TVHExchangetvhc_";

        type="multipart/alternative"

MIME-Version: 1.0

Van R. Johnson