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441 4.4.1 Error encountered when sending email from Exchange 2013 to Sharepoint 2010

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I have just started working at a new location. A predecessor has created  a send connector from our Exchange 2013 to an internal SharePoint 2010 site.

The sharepoint server is running smtp and can receive mail if I telnet to the from the local host to itself on port 25. Hence an .eml message arrives inC:\inetpub\mailroot\Drop on the SharePoint box.

However, when ever I try to send a message to the SharePoint server from exchange, the message is queued for delivery, but the message gets stuck in the mail queue.

Delayed message from Exchange:

Remote Server at sharepointsvr.domain.com (xxx.xxx.xxx.xxx) returned '400 4.4.7 Message delayed'

3/11/2016 3:07:21 AM - Remote Server at
sharepointsvr.domain.com (xxx.xxx.xxx.xxx) returned '441 4.4.1 Error encountered while communicating with primary target IP address: "421 4.4.2 Connection dropped due to SocketError." Attempted failover to alternate host, but that did not succeed. Either there are no alternate hosts, or delivery failed to all alternate hosts. The last endpoint attempted was xxx.xxx.xxx.xxx:25'

Does anyone have any suggestions?

You will receive much praise!


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