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unable to send message internally from exchange 2013

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Hi All,

We have Single AD site where we have Datacenter 1 and Dtacenter 2.

In DC 1 we have 2 Mailbox/CAs server and in DC 2 we have single CAS/MBX server.

All server are member of DAG.

Now the issue is internal mail flow working sometime , and sometime not working .

When i check the mail queue it is shwoing below error message.

LED=441 4.4.1 Error encountered while communicating
with primary target IP address: "Failed to connect. Winsock error code 10061,
Win32 error code 10061." Attempted failover to alternate host, but that did not
succeed. Either

All serers are multi role servers.

DNS is properly configured, Network binding and ip config is perfect.

All services are working fine. ABle to telnet and send the messges but message stuck in quest wiht same error message.

ABle to send external message wihtout any issue.

Thanks in advance


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