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550 relay not permitted

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Hi,
we have exchange 2013 in our organization, we want one client to use pop3 and smtp server at outside organization (but pc physicaly in our office). This computer has outlook configured with smtp.other.com and pop3.other.com . But when sending mail to anyone outside company he gets Server error: '550 Relay not permitted' . First of all I thought it is firewall issue. But it has no logs for this mail. 

I also added into accepted domain in exchange as an external relay, but it does not changed anythig. Is this an exchange issue? Because I though if I'm sending email to outside smtp server it bypasses internal exchange. If it is a case where can i enable authentication for that outside mail in exchange?

Should i create send connector? 

Also I can send to internal mailboxes, but when replying firewall just shows it is delivered to exchange edge server. How can I troubleshoot reply message from there?

EDIT: After a 15min i  got 554 5.4.6 Hop count exceeded - possible mail loop








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