Receive connector error : 452 4.3.1 Insufficient system resources. No back pressure event

Hi ,

I have Exchange 2013 server configured as a multirole (cas+mbx) that is rejecting messages .

I started the verbose logging of the receive connector and notice that sometimes the response from the server was

452 4.3.1 Insufficient system resources.

I don't have back pressure events and my Transport Database has a lot of free space.

Any ideas ?

Exchange 2013 CU7

Error from managed availability

Mailbox Transport Submission - the verification that the probe messages were successfully submitted within 5 minutes to HUB has failed.
      This could indicate that the mailbox submissions are taking too long or not progressing at all.
      SequenceNumber: 635708989783012831

      Error: MapiSubmitLAMProbe finished with CheckPreviousMail failure.
      FailureContext: MapiSubmitLAMProbe finished with CheckPreviousMail failure.
      ExecutionContext: MapiSubmitLAMProbe started. This performs - 1. Submits a new message to Store 2. Checks results from previous Send Mail operation. Sequence # = 635708989783012831. First Run? = False. Previous mail submission to store was successful. Results -  # of previous results: 0.  Could Not Find stages that ran.  Previous SendMail failure -  Mail submitted to Store during the previous run never reached SendAsCheck.
                        This may indicate a latency from Store to Submission Service. Investigating.  Found lower SA latency. Indicates an issue in Submission service.
                            Investigate. In SendMail -  NotificationID=00000050-0000-0000-0000-00004489f5df Sending mail. SendMail finished. MapiSubmitLAMProbe finished with CheckPreviousMail failure.
      CheckPreviousRunMail exception details:
      Current SendMail exception details:

      MailWasSentInLastRun (0(no)/1(yes)): 1
      CheckMailSuccess(0(no)/1(yes)): 0
      SendMailSuccess(0(no)/1(yes)/2(no-noMDBs)/3(no-noActiveMDBs)/4(no-ignorableException)): 1

      PreviousMailLatencies: <2816a467fc6e4df58602517b149c0d3d@ex01.cosanostra-bg.com>,,2015-06-29T19:24:24.120Z;LSRV=ex01.cosanostra-bg.com:TOTAL-SUB=0.515|SA=0.031|MTSSDPL=0.011|MTSSDSS=0.013;;<c553276a7fdc48bb971696959d0d2e12@ex01.cosanostra-bg.com>,,2015-06-29T19:19:24.074Z;LSRV=ex01.cosanostra-bg.com:TOTAL-SUB=0.312|SA=0.031|MTSSDPL=0.011|MTSSDSS=0.012;;<555848d05c0e4141a7c441ff0fdb294b@ex01.cosanostra-bg.com>,,2015-06-29T19:14:23.902Z;LSRV=ex01.cosanostra-bg.com:TOTAL-SUB=5.593|SA=5.249|MTSSDPL=0.006|MTSSDSS=0.014;;
      GetPreviousMailLatencyFailures:

      (The following are applicable if the mail was actually sent)
      MailSentAt: 29.6.2015 19:29:24
      TimeInSendingToStore: 125,0239
      Sent Mail Result Details:
        (InternetMessageId:<3fd1eb6e77e74b78a40ebd213ca3dbd9@ex01.cosanostra-bg.com>;
        ItemEntryId:0 0 0 0 B2 A1 18 B5 9C ED 46 4E 9A BE D6 7B 72 A 16 42 7 0 F6 1E 9B BD D4 78 81 4E 82 A BD AE 4 39 B5 43 0 0 0 0 1 B 0 0 F6 1E 9B BD D4 78 81 4E 82 A BD AE 4 39 B5 43 0 0 44 C5 DF 36 0 0 )
        Properties of Sending mail
        (Subject:00000050-0000-0000-0000-00004489f5df-MapiSubmitLAMProbe;
        Sender:HealthMailboxad7d1178cd2f4d89a176adf4adfcd908@cosanostra-bg.com;
        MbxGuid:b3d5201b-e40b-4987-b335-385fb733c354;
        MdbGuid:2a1cd6fa-6435-4ab1-82b2-8b9654e4ee94;
        Recipient:HealthMailboxad7d1178cd2f4d89a176adf4adfcd908@cosanostra-bg.com;
        Body and MessageClass:MessageClass:IPM.Note.MapiSubmitLAMProbe;MessageBody:This is a Probe Mapi message that's Submitted from Store to Mailbox transport Submission service to Hub transport service;
        DoNotDeliver, DropMessageInHub and DeleteAfterSent:DoNotDeliver:True;DropMessageInHub:True;DeleteAfterSubmit:True;)
Probe Exception: 'System.ApplicationException: MapiSubmitLAMProbe finished with CheckPreviousMail failure.
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Transport.Probes.MapiSubmitLAMProbe.PerformProbeFinalAction(Boolean potentialForAlertBasedOnPreviousRun, Boolean potentialForAlertBasedOnCurrentRun, Exception previousRunVerificationException, Exception currentRunException, DateTime timeMessageSentToStore)
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Transport.Probes.MapiSubmitLAMProbe.DoWorkInternal(CancellationToken cancellationToken)
   at Microsoft.Forefront.Monitoring.ActiveMonitoring.Transport.Probes.MapiSubmitLAMProbe.DoWork(CancellationToken cancellationToken)
   at Microsoft.Office.Datacenter.WorkerTaskFramework.WorkItem.Execute(CancellationToken joinedToken)
   at Microsoft.Office.Datacenter.WorkerTaskFramework.WorkItem.<>c__DisplayClass2.<StartExecuting>b__0()
   at System.Threading.Tasks.Task.Execute()'
Probe Result Name: 'Mapi.Submit.Probe'
Probe Result Type: 'Failed'
Monitor Total Value: '0'
Monitor Total Sample Count: '12'
Monitor Total Failed Count: '12'
Monitor Poisoned Count: '0'
Monitor First Alert Observed Time: '26.6.2015 7:17:58'